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邓海腾  博士

教授


1985    武汉大学   学士     
1988    武汉大学    硕士     
1996    Pennsylvania State University      博士
University of Alberta                    博士后
Oak Ridge National Laboratory    博士后
1/2000-12/2001 讲师,发育生物学系,爱因斯坦医学院
12/2001-7/2003 助理教授,医学系,爱因斯坦医学院
8/2003-12/2003 助理教授,内布拉斯加大学
1/2004-7/2009   研究助理教授,洛克菲勒大学
9/2009-2/2011   研究副教授和蛋白质组中心主任,洛克菲勒大学
9/2008-Present  客座研究员,纽约大学
3/2011-Present  客座教授,洛克菲勒大学
3/2011-Present  教授(2017年),清华大学

 

●  研究兴趣、领域:


发展和应用蛋白质组学、代谢组学和化学生物学的技术和方法。研究氧化还原生物学在衰老和疾病中的功能和作用机制。发展衰老及其疾病相关的生物标志物。开发提高健康寿命的天然小分子、纳米抗体和疫苗。研究病原微生物-宿主细胞的相互作用。 鉴定肿瘤早期诊断的标记物并研究蛋白质药物的修饰和作用机制。


●  代表性论文:


1. Wang W, Yang C, Wang T, Deng H., Complex roles of nicotinamide N-methyltransferase in cancer progression. Cell Death Dis. 2022 Mar 25;13(3):267.

2. Yang C, Zhu S, Chen Y, Liu Z, Zhang W, Zhao C, Luo C, Deng H.,Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation. Free Radic Biol Med. 2021 Nov 1; 175:206-215.

3. Songbiao Zhu; Wenxi Ding; Yuling Chen; Weixuan Wang; Renhua Xu; Chongdong Liu; Xiaohui Liu; Haiteng Deng,High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumour Cells,Genomics, Proteomics & Bioinformatics,2021 Feb 26:S1672-0229.

4. Liu, Yan; Luo, Chengting; Li, Ting; Zhang, Wenhao; Zong, Zhaoyun; Liu, Xiaohui; Deng, Haiteng,Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Suppresses Glycolysis, TCA Cycle and Cell Growth,J Proteome Res. 2021 May 7;20(5):2596-2606.

5. Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H., Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages. Front Mol Biosci. 2021 Jul 6;8:702107.

7. Jin J, Meng X, Huo Y, Deng H., Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting. Cell Death Dis. 2021 Jul 13;12(7):697.

8. Zong Z, Liu J, Wang N, Yang C, Wang Q, Zhang W, Chen Y, Liu X, Deng H., Nicotinamide Mononucleotide Inhibits Hepatic Stellate Cell Activation to Prevent Liver Fibrosis via Promoting PGE2 Degradation., Free Radic Biol Med. 2021 Jan;162:571-581.

9. Meiqi Yi, Yingying Ma, Yuling Chen, Chongdong Liu, Qingtao Wang, and Haiteng Deng. Glutathionylation decreases methyltransferase activity of PRMT5 and inhibits cell proliferation. Mol Cell Proteomics. 2020 Nov;19(11):1910-1920.

10. Meiqi Yi, Yingying Ma, Songbiao Zhu, Chengting Luo, Yuling Chen, Qingtao Wang, Haiteng Deng. Comparative proteomic analysis identifies biomarkers for renal aging. Aging (Albany NY). 2020 Nov 6;12(21):21890-21903.

11. Zhang, Lin; Shen, Hao; Gong, Yiyi; Pang, Xiaojing; Yi, Meiqi; Guo, Lin; Li, Jin; Arroyo, Sam; Lu, Xin; Ovchinnikov, Sergey; Cheng, Gong; Liu, Xudong; Jiang, Xu; Feng, Shan; Deng, Haiteng; Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking, Chemical Science, 2019, 10(11): 3271-3280.

12. Teng, Ruifang; Liu, Zhilei; Tang, Haiping; Zhang, Wenhao; Chen, Yuling; Xu, Rrenhua; Chen, Liang; Song, Jiangping; Liu, Xiaohui; Deng, Haiteng; HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells, Redox Biology, 2019, 24: 101218.

13. Chen P, Wang H, Zhang W, Chen Y, Lv Y, Wu D, Guo M Sr, Deng H.,Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells. Molecular Cell Proteomics. 2019 Jul;18(7):1320-1329.

14. Wang, Weixuan; Hu, Yadong; Wang, Xiaofei; Wang, Qingtao; Deng, Haiteng*; ROS-mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition, Cell Chemical Biology, 2018, 25: 1-7.

15. Wang, Weixuan; Hu, Yadong; Yang, Changmei; Zhu, Songbiao; Wang, Xiaofei; Zhang, Zhenyu; Deng, Haiteng*; Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition, Molecular Cell Proteomics, 2018, 17(10): 2005-2017.


丛书章节
1. 邓海腾,陈宇凌,陈香梅,《蛋白质组学与精准医学》,2018,国家出版社
2. J-R Zhang, MG Marinus, H Deng, Methylation and other Modifications of Nucleic Acids and Proteins, Reference Module in Biomedical Sciences, 2015 Elsevier Inc.
3. Amanda Chen, Haiqiang Yu, Haiteng Deng and W. Beau Mitchell, Mechanisms of αIIbβ3 Biogenesis in the Megakaryocyte: A Proteomics Approach in Hematology - Science and Practice, Edited by Charles H. Lawrie, ISBN 978-953-51-0174-1, Publisher: InTech, March 02, 2012 DOI: 10.5772/2259.
4. Haiteng Deng, Proteomics in Drug Discovery in Handbook of Drug Screening, R. Seethala, Eds, Informa Healthcare, May 2009.
5. Denis L. Rousseau, David Li, Eric Y. Hayden, Haiteng Deng and Syun-Ru Yeh, Protein-ligand interactions in mammalian nitric oxide synthase, in THE SMALLEST BIOMOLECULES: DIATOMICS AND THEIR INTERACTIONS WITH HEME PROTEINS, Abhik Ghosh, Eds, Elsevier, Dec 2007.



●  荣誉、奖励及参加学术团体的情况:


会员
The New York Academy of Science; The American Chemical Society; The American Society for Mass Spectrometry

●  联系方式:


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电话:+86-10-62789415
邮箱:dht@mail.tsinghua.edu.cn