银河国际app手机版下载 - 最新版APP Store

   

张强锋 博士

副教授


1996-2000 中国科学技术大学 学士
2000-2006 中国科学技术大学 博士
2006-2011 哥伦比亚大学 博士
2011-2012 哥伦比亚大学 博士后
2012-2015 斯坦福大学医学院 博士后
2015-2018 银河国际app手机版下载 - 最新版APP Store 助理教授
2018-至今 银河国际app手机版下载 - 最新版APP Store 副教授

●  研究兴趣、领域:


我们实验室是一个结构生物学、基因组学、人工智能和大数据分析等多学科交叉实验室。我们主要的研究兴趣是发展高通量实验新技术,结合机器学习等计算方法,应用于新兴的结构系统生物学研究。其中包括RNA结构测序技术及算法、单细胞基因组结构测序技术及算法、蛋白质结构建模、大分子相互作用网络等。我们还感兴趣结合结构和网络,深入研究复杂疾病(如癌症)和RNA病毒传染性疾病的传播机制,在此基础上发展可能的诊断、预后及治疗手段。

●  代表性论文:


1. Meiling Piao, Pan Li, Xiaomin Zeng, Xi-Wen Wang, Lan Kang, Jinsong Zhang, Yifan Wei, Shaojun Zhang, Lei Tang, Jianghui Zhu, Chun Kit Kwok, Xiaoyu Hu#, Qiangfeng Cliff Zhang# (2022) An ultra low-input method for global RNA structure probing uncovers Regnase-1-mediated regulation in macrophages, Fundamental Research 2 (1), 2-13

2. Shaojun Zhang*, Wenze Huang*, Lili Ren*, Xiaohui Ju*, Mingli Gong*, Jian Rao*, Lei Sun, Pan Li, Qiang Ding#, Jianwei Wang#, Qiangfeng Cliff Zhang# (2022) Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2, Cell Research 32 (1), 9-23

3. Jing Gong*, Kui Xu*, Ziyuan Ma, Zhi John Lu, Qiangfeng Cliff Zhang# (2021) A deep learning method for recovering missing signals in transcriptome-wide RNA structure profiles from probing experiments, Nature Machine Intelligence 3 (11), 995-1006

4. Qing-Jun Luo*, Jinsong Zhang*, Pan Li*, Qing Wang, Yue Zhang, Biswajoy Roy-Chaudhuri, Jianpeng Xu, Mark A. Kay#, Qiangfeng Cliff Zhang# (2021) RNA structure probing reveals the structural basis of Dicer binding and cleavage, Nature Communications 12 (1), 1-12

5. Lei Sun*, Pan Li*, Xiaohui Ju*, Jian Rao*, Wenze Huang*, Lili Ren, Shaojun Zhang, Tuanlin Xiong, Kui Xu, Xiaolin Zhou, Mingli Gong, Eric Miska, Qiang Ding#, Jianwei Wang#, Qiangfeng Cliff Zhang#. (2021) In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs, Cell 184(7):1865-1883. e20

6. Lei Sun*, Kui Xu*, Wenze Huang*, Yucheng Yang*, Lei Tang, Tuanlin Xiong, Qiangfeng Cliff Zhang#. (2021) Predicting dynamic cellular protein-RNA interactions using deep learning and in vivo RNA structure, Cell Research 31(5):495-516

7. Boyang Shi*, Jinsong Zhang*, Jian Heng*, Jing Gong*, Ting Zhang, Pan Li, Bao-Fa Sun, Ying Yang, Ning Zhang, Yong-Liang Zhao, Hai-Lin Wang, Feng Liu#, Qiangfeng Cliff Zhang#, Yun-Gui Yang#. (2020) RNA structural dynamics regulates early embryogenesis through controlling transcriptome fate and function, Genome Biology 21(1):1-27.

8. Xiaocheng Weng*, Jing Gong*, Yi Chen, Tong Wu, Fang Wang, Shixi Yang, Yushu Yuan, Guanzheng Luo, Kai Chen, Lulu Hu, Honghui Ma, Pingluan Wang, Qiangfeng Cliff Zhang#, Xiang Zhou#, Chuan He#. (2020)  Keth-seq for transcriptome-wide RNA structure mapping. Nature Chemical Biology 16(5):489-492

9. Lei Xiong*, Kui Xu, Kang Tian, Yanqiu Shao, Lei Tang, Ge Gao, Michael Zhang, Tao Jiang, Qiangfeng Cliff Zhang#. (2019) SCALE: Single-cell ATAC-seq analysis via latent feature extraction. Nature Communications 10:4576

10. Lei Sun*, Furqan M Fazal*, Pan Li*, James P Broughton, Byron Lee, Lei Tang, Wenze Huang, Eric T Kool, Howard Y Chang#, Qiangfeng Cliff Zhang#. (2019) RNA structure maps across mammalian cellular compartments. Nature structural & molecular biology 26(4):322-330

11. Kui Xu*, Zhe Wang, Jianping Shi, Hongsheng Li, Qiangfeng Cliff Zhang#. (2019) A2-Net: Molecular Structure Estimation from Cryo-EM Density Volumes. In the Proceedings of the Thirty-Fourth AAAI Conference on Artificial Intelligence (AAAI 2019):1230-1237. Jan. 27-Feb.1, Hawaii, USA

12. Pan Li*, Yifan Wei*, Miao Mei*, Lei Tang*, Lei Sun, Wenze Huang, Jianyu Zhou, Chunlin Zou, Shaojun Zhang, Cheng-feng Qin, Tao Jiang, Jianfeng Dai, Xu Tan#, Qiangfeng Cliff Zhang#. (2018) Integrative Analysis of Zika Virus Genome RNA Structure Reveals Critical Determinants of Viral Infectivity. Cell Host & Microbe 24(6):875-886


 


●  联系方式:


电子邮件:qczhang@tsinghua.edu.cn

电话:010-6279-6439(办公室),010-6279-5823(实验室)

主页: http://zhanglab.net