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王新泉 博士

教授


1990-1995, 复旦大学 学士

1995-2000, 中国科学院生物物理研究所 博士

2000-2003, 中国科学院生物物理研究所 助理研究员

2003-2008, 美国斯坦福大学 博士后

2008-2013 清华大学生命学院,准聘副教授

2013-至今 清华大学生命学院,长聘教授

 

●  研究兴趣、领域:


主要研究方向为结构生物学。利用X-射线晶体学为主要研究手段,结合其他生物化学及生物物理技术,研究细胞因子介导的宿主免疫反应和病毒侵染及免疫逃逸的结构机理。

 

●  代表性论文:


1. Zhang S, Liang Q, He X, Zhao C, Ren W, Yang Z, Wang Z, Ding Q, Deng H, Wang T*, Zhang L*, Wang X*. Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2. Cell Res. (2022) 32(3):315-318.

2. Ge J, Wang R, Ju B, Zhang Q, Sun J, Chen P, Zhang S, Tian Y, Shan S, Cheng L, Zhou B, Song S, Zhao J, Wang H, Shi X, Ding Q, Liu L, Zhao J, Zhang Z*, Wang X*, Zhang L*. (2021) Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nature Communications, 12(1):250.

3. Zhang, S., Qiao, S., Yu, J., Zeng, J. & Wang, X*.(2021). Bat and pangolin coronavirus spike glycoprotein structures provide insights into sars-cov-2 evolution. Nature Communications, 12(1), 1607.

4. Yu J, Qiao S, Guo R & Wang X*. Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. Nat Commun 11, 3070, doi: 10.1038/s41467-020-16876-4 (2020)

5. Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L & Wang X*. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. Mar 30. doi: 10.1038/s41586-020-2180-5. [Epub ahead of print] (2020).

6. Zhou H, Chen Y, Zhang S, Niu P, Qin K, Jia W, Huang B, Zhang S, Lan J, Zhang L, Tan W & Wang X*. Structural definition of a neutralization epitope on the n-terminal domain of mers-cov spike glycoprotein. Nat Commun 10, 3068, doi:10.1038/s41467-019-10897-4 (2019).

7. Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S & Wang X*. Functional relevance of interleukin-1 receptor inter-domain flexibility for cytokine binding and signaling. Structure 27, 1296-1307 e1295, doi:10.1016/j.str.2019.05.011 (2019).

8. Zhang S, Zhou P, Wang P, Li Y, Jiang L, Jia W, Wang H, Fan A, Wang D, Shi X, Fang X, Hammel M, Wang S, Wang X* & Zhang L. Structural definition of a unique neutralization epitope on the receptor-binding domain of mers-cov spike glycoprotein. Cell Rep 24, 441-452, doi:10.1016/j.celrep.2018.06.041 (2018).

9. Song W, Gui M, Wang X* & Xiang Y. Cryo-em structure of the sars coronavirus spike glycoprotein in complex with its host cell receptor ace2. PLoS Pathog 14, e1007236, doi:10.1371/journal.ppat.1007236 (2018).

10. Gui M, Song W, Zhou H, Xu J, Chen S, Xiang Y & Wang X*. Cryo-electron microscopy structures of the sars-cov spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res 27, 119-129, doi:10.1038/cr.2016.152 (2017).

11. Jiang L, Wang N, Zuo T, Shi X, Poon KM, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng BJ, Wang X* & Zhang L. Potent neutralization of mers-cov by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Sci Transl Med 6, 234ra259, doi:10.1126/scitranslmed.3008140 (2014).

12. Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L & Wang X*. Structure of mers-cov spike receptor-binding domain complexed with human receptor dpp4. Cell Res 23, 986-993, doi:10.1038/cr.2013.92 (2013).

13. Wang D, Huang B, Zhang S, Yu X, Wu W & Wang X*. Structural basis for r-spondin recognition by lgr4/5/6 receptors. Genes Dev 27, 1339-1344, doi:10.1101/gad.219360.113 (2013).

14. Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S & Wang X*. Structural insights into the interaction of il-33 with its receptors. Proc Natl Acad Sci U S A 110, 14918-14923, doi:10.1073/pnas.1308651110 (2013).

15. Wang D, Zhang S, Li L, Liu X, Mei K & Wang X*. Structural insights into the assembly and activation of il-1beta with its receptors. Nat Immunol 11, 905-911, doi:10.1038/ni.1925 (2010).

 

●  联系方式:

             

E-mail: xinquanwang@mail.tsinghua.edu.cn