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葛亮 博士

副教授


2001-2005年,山东师范大学生命科学院                  学士

2005-2011年,中科院上海生化细胞所                      生物化学博士

2011-2015年,美国加州大学伯克利分校                  博士后

2015-2017年,美国加州大学伯克利分校                  研究员(Research Specialist)

2017-               银河国际app手机版下载 - 最新版APP Store-生命科学联合中心  副教授

 

●  研究兴趣、领域:


生命的本质之一是生物体独立于外界建立自我维持的代谢稳态调节环境,并能应对和抵抗外界压力和刺激。我们致力于解答“细胞在外界压力下如何维持内部稳态平衡?”这一细胞生物学的本质问题。我们研究主要集中在三个相互关联的细胞学过程:细胞自噬(应激状态下细胞自我清理和更新内部物质的过程)、非经典分泌(近来发现的应激状态下不依赖于传统内质网高尔基体运输的分泌过程)和细胞器互作(细胞器之间通过接触相互协作调控细胞生命活动和应激的过程)。我们运用细胞生物学、生物化学、动物模型和计算生物学等手段,研究这三个过程的细胞内调节和相互作用的分子机制,以及其生物学意义和相关人类疾病。

●  代表性论文:


1. Xinyu Ma, Caijing Lu, Yuting Chen, Shulin Li, Ningjia Ma, Xuan Tao, Ying Li, Jing Wang, Min Zhou, Yong-Bin Yan, Pilong Li, Kartoosh Heydari, Haiteng Deng, Min Zhang*, Cong Yi*, and Liang Ge*. CCT2 is an aggrephagy receptor for clearance of solid protein aggregates. Cell (2022) 185:1325-1345 (Highlighted in Nature Reviews Cell Biology [Paulina Strzyz. Chaperoning solid aggregates for autophagy. Nature Reviews Cell Biology (2022)] and by Christian Behrends in Molecular Cell [Dorothee Dormann & Christian Behrends. Only solid waste, please! Molecular Cell (2022) 82:1408-1410]).

2. Shulin Li, Rui Yan, Jialu Xu, Shiqun Zhao, Xinyu Ma, Qiming Sun, Min Zhang, Ying Li, Jun-Jie Gogo Liu, Liangyi Chen, Sai Li, Ke Xu, and Liang Ge*. A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis. Cell Research (2022) 32:119–138. (Highlighted by David Rubinsztein [Claudia Puri & David C. Rubinsztein. TMED9–SEC12, an important “contact” for autophagy. Cell Research (2022) 32:111–112])

3. Min Zhang#, Lei Liu#, Xubo Lin, Yang Wang, Qing Guo, Ying Li, Shulin Li, Yuxin Sun, Di Zhang, Xiachen Lv, Li Zheng and Liang Ge*. A translocation pathway for vesicle-mediated unconventional protein secretion. Cell (2020) 181:637-652. Selected for F1000Prime; Highlighted by Jayanta Debnath [Tan A. Nguyen & Jayanta Debnath. Unconventional secretion: cargo channeling by TMED10. Cell Research (2020)]

4. Liang Ge*, Min Zhang, Sam Kenny, Anandita Mathur, Dawei Liu, Miharu Maeda, Kota Saito, Ke Xu, and Randy Schekman. Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis. EMBO Rep. (2017) 18(9):1586-1603. Selected for F1000Prime

5. Min Zhang, Sam Kenny, Liang Ge, Ke Xu and Randy Schekman. Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion. eLife (2015) Nov;10.7554/eLife.11205. Selected for F1000Prime

6. Liang Ge, Min Zhang and Randy Schekman. Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. eLife (2014) Nov 28; 3:e04135.

7. Liang Ge, David Melville, Min Zhang and Randy Schekman. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. eLife (2013) Aug 6; 2:e00947. Selected for F1000Prime and highlighted by Daniel Klionsky [Amélie Bernard and Daniel J Klionsky. Defining the membrane precursor supporting the nucleation of the phagophore. Autophagy (2014) 10(1):1-2].


 

●  荣誉、奖励及参加学术团体的情况:


中国生物物理学会亚细胞器结构与功能分会副会长

中国细胞生物学会细胞器分会副秘书长

NIH Pathway to Independence Award (K99/R00) (2015-2017)

Jane Coffin Child Foundation Fellowship (2013-2015)

Human Frontier Science Program Fellowship (2012)

 

●  联系方式:


电话:86-10-62789019 (实验室)      

E-mail: liangge@mail.tsinghua.edu.cn